MK-801 (Dizocilpine)
MK-801 (Dizocilpine)(MK-801 (Dizocilpine))
CAS: 77086-21-6
化学式: C16H15N
| 中文名 | MK-801 (Dizocilpine) |
| 英文名 | MK-801 (Dizocilpine) |
| 别名 | 地佐环平 地卓西平 |
| 英文别名 | C13737 Dizocilpine MK-801 (Dizocilpine) Dizocilpine free base(MK801) (5S)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5α,10α-imine 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)- [5S,10R,(+)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine [5S,10R,(+)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5α,10α-imine |
| CAS | 77086-21-6 |
| 化学式 | C16H15N |
| 分子量 | 221.3 |
| 密度 | 1.144±0.06 g/cm3(Predicted) |
| 熔点 | 68.5-69° |
| 沸点 | 320.3±11.0 °C(Predicted) |
| 比旋光度 | 20589 +161.4° (c = 0.038 g/2 ml ethanol) |
| 酸度系数 | 7.96±0.40(Predicted) |
| 存储条件 | -20℃ |
| 体外研究 | Dizocilpine (MK-801) progressively suppresses of current induced by NMDA. Mg 2+ (10 mM) prevents Dizocilpine from blocking the N-Me-D-Asp-induced current, even when Dizocilpine is applied for a long time in the presence of NMDA. Dizocilpine blocks NMDA-activated single-channel activity in outside-out patches. Dizocilpine (MK-801; <500 μM) inhibits activation of microglia induced by LPS with increased Cox-2 protein expression in BV-2 cells. Dizocilpine (<500 μM) reduces microglial TNF-α output with an EC 50 of 400 μM in BV-2 cells. |
| 体内研究 | Dizocilpine (MK 801) (1 mg/kg) treatment before each METH injection reduces the extent of DA depletion by 55% in striatal of mice. Dizocilpine (MK 801) (1 mg/kg) also attenuates the effects of METH on microglial activation in striatal of mice. Dizocilpine ((+)-MK 801) (0.05, 0.2 mg/kg, i.p.) attenuates subsequent cocaine-primed reinstatement without disruption in rats. Dizocilpine (MK 801) (0.2 mg/kg, i.p.) prior to two reactivation sessions in the home cage shows no suppression on subsequent cocaine-primed reinstatement. Dizocilpine (0.03, 0.1, 0.3 and 1 mg/kg, i.p.) significantly increases the ambulation of mice at 0.3 and 1 mg/kg, but not at 0.03 and 0.1 mg/kg. |
MK-801 (Dizocilpine) - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.519 ml | 22.594 ml | 45.188 ml |
| 5 mM | 0.904 ml | 4.519 ml | 9.038 ml |
| 10 mM | 0.452 ml | 2.259 ml | 4.519 ml |
| 5 mM | 0.09 ml | 0.452 ml | 0.904 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: (5S,10R)-5-甲基-10,11-二氢-5H-5,10-桥亚氨基二苯并[a,d][7]轮烯 去供应商网站查看 询盘CAS: 77086-21-6
产地: 上海
规格: D914358
价格: 100mg-3450,25mg-1280,5mg-480
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: MK-801 (Dizocilpine) 去供应商网站查看 询盘CAS: 77086-21-6
产地: 上海
规格: 98%
价格: 5mg 400,10mg 640,25mg 1040,50mg 1760,100mg 2720
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: MK-801 (Dizocilpine) 98% MedMol 货号：S88179
现货供应
产品名: (5S,10R)-5-甲基-10,11-二氢-5H-5,10-桥亚氨基二苯并[a,d][7]轮烯 去供应商网站查看 询盘CAS: 77086-21-6
产地: 上海
规格: D914358
价格: 100mg-3450,25mg-1280,5mg-480
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: MK-801 (Dizocilpine) 去供应商网站查看 询盘CAS: 77086-21-6
产地: 上海
规格: 98%
价格: 5mg 400,10mg 640,25mg 1040,50mg 1760,100mg 2720
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: MK-801 (Dizocilpine) 98% MedMol 货号：S88179
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